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[1] Lu, T. L., Li, S. R., Zhang, J. M., & Chen, C. W. (2022). Meta-analysis on the epidemiology of gastroesophageal re铿倁x disease in China. World journal of gastroenterology, 28(45), 6410鈥?420.
[2] Wang, K., Zhang, L., He, Z. H., Liu, Z. J., Zhang, L., Hu, N., Jin, Z., Ke, Y., & Duan, L. P. (2019). A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China. Chinese medical journal, 132(13), 1516鈥?523.
[3] 瀹侀泤濠? 姹繝闀? & 鍒樼櫥绉? (2010). 鑳冮绠″弽娴佺梾1014渚嬩綇闄㈡偅鑰呯殑璇婃不鍒嗘瀽. 涓崕鏅绉戞墜鏈鏉傚織锛堢數瀛愮増锛?(3):264-270.
[4] 姹繝闀? (2017). 椋熺鍙嶆祦涓庡懠鍚搁亾鐤剧梾:鑳冮绠″枆姘旂缁煎悎寰? 浜烘皯鍗敓鍑虹増绀?
[5] 璐甸槼甯傜櫧浜戝尯浜烘皯鍖婚櫌. (2025). 澶滈棿鍜冲枠鐪熺浉锛?0%鍝枠绔熸槸鑳冮绠″弽娴佷吉瑁? Retrieved 6 May 2025 from https://mp.weixin.qq.com/s/K6lZrP1VaLjz02-flaKhcw.
[6] 鍖椾含闈掑勾鎶? (2021). 7涓敮鏋堕兘娌℃牴娌荤殑鑳哥棝 绔熸槸鑳冮绠″弽娴佸湪浣滄€? Retrieved 6 May 2025 from https://epaper.ynet.com/html/2021-07/15/content_379102.htm?div=-1.
[7] 榛樻矙涓滆瘖鐤楁墜鍐屽ぇ浼楃増. (2024). 鑳冮绠″弽娴佺梾 (GERD). Retrieved 6 May 2025 from https://www.msdmanuals.cn/home/digestive-disorders/esophageal-and-swallowing-disorders/gastroesophageal-reflux-disease-gerd.
[8] Yuan, L. Z., Yi, P., Wang, G. S., Tan, S. Y., Huang, G. M., Qi, L. Z., ... & Wang, F. (2019). Lifestyle intervention for gastroesophageal reflux disease: a national multicenter survey of lifestyle factor effects on gastroesophageal reflux disease in China. Therapeutic advances in gastroenterology, 12, 1756284819877788.
[9] Nehlig A. (2022). Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update. Nutrients, 14(2), 399.
[10] Berquist, W. E., Rachelefsky, G. S., Kadden, M., Siegel, S. C., Katz, R. M., Mickey, M. R., & Ament, M. E. (1981). Effect of theophylline on gastroesophageal reflux in normal adults. Journal of Allergy and Clinical Immunology, 67(5), 407-411
[11] 鍛ㄩ噾姹? 绐︾淮浣? 榄忓欢, 璧垫洐鍏? 闊╀紵, 绋嬫旦, & 鍒橀渿闆? (2021). 涓浗鑳冮绠″弽娴佺梾鎮ｈ€呯劍铏戞姂閮佹偅鐥呯巼鐨 Meta 鍒嗘瀽. 涓浗鍏ㄧ鍖诲, 24(5), 608-613.
[12] Jansson, C., Nordenstedt, H., Wallander, M. A., Johansson, S., Johnsen, R., Hveem, K., & Lagergren, J. (2007). Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study. Alimentary pharmacology & therapeutics, 26(5), 683鈥?91.
[13] Clarrett, D. M., & Hachem, C. (2018). Gastroesophageal Reflux Disease (GERD). Missouri medicine, 115(3), 214鈥?18.
[14] Preetha, A., Sujatha, D., Patil, B. A., & Hegde, S. (2015). Oral manifestations in gastroesophageal reflux disease. General dentistry, 63(3), e27鈥揺31.
[15] Struch, F., Schwahn, C., Wallaschofski, H., Grabe, H. J., V枚lzke, H., Lerch, M. M., Meisel, P., & Kocher, T. (2008). Self-reported halitosis and gastro-esophageal reflux disease in the general population. Journal of general internal medicine, 23(3), 260鈥?66.
[16] Tran, C. L., Han, M., Kim, B., Park, E. Y., Kim, Y. I., & Oh, J. K. (2023). Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort. Cancer medicine, 12(18), 19163鈥?9173.
[17] 涓崕鍖诲浼氭秷鍖栫梾瀛﹀垎浼? (2020). 2020骞翠腑鍥借儍椋熺鍙嶆祦鐥呬笓瀹跺叡璇? 涓崕娑堝寲鏉傚織, 40(10) : 649-663.
[18] Zhang, M., Hou, Z. K., Huang, Z. B., Chen, X. L., & Liu, F. B. (2021). Dietary and Lifestyle Factors Related to Gastroesophageal Reflux Disease: A Systematic Review. Therapeutics and clinical risk management, 17, 305鈥?23.
[19] Heidarzadeh-Esfahani, N., Soleimani, D., Hajiahmadi, S., Moradi, S., Heidarzadeh, N., & Nachvak, S. M. (2021). Dietary Intake in Relation to the Risk of Reflux Disease: A Systematic Review. Preventive nutrition and food science, 26(4), 367鈥?79.